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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Paeonol, Paclitaxel
Phytochemical Name Paeonol (PubChem CID: 11092 )
Anticancer drug Name Paclitaxel (PubChem CID: 36314 )
Structure of
Phytochemical
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2D MOL 3D MOL
Structure of
Anticancer Drug
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Reversing Drug Resistance
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Combination Pair ID: 1043
Pair Name Paeonol, Paclitaxel
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Gene Regulation Down-regulation Expression BCRP KEGG ID N.A.
Down-regulation Expression MRP1 KEGG ID N.A.
Down-regulation Expression P-gp KEGG ID N.A.
Down-regulation Expression transgelin 2 KEGG ID N.A.
In Vitro Model MCF-7/PTX Invasive breast carcinoma of no special type Homo sapiens (Human) CVCL_C5RS
Result These results not only provide insight into the potential application of paeonol to the reversal of paclitaxel resistance, thus facilitating the sensitivity of breast cancer chemotherapy, but also highlight a potential role of transgelin 2 in the development of paclitaxel resistance in breast cancer.
03. Reference
No. Title Href
1 Paeonol reverses paclitaxel resistance in human breast cancer cells by regulating the expression of transgelin 2. Phytomedicine. 2014;21(7):984-991. doi:10.1016/j.phymed.2014.02.012 Click
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