Pair Name | Paeonol, Paclitaxel | ||
Phytochemical Name | Paeonol (PubChem CID: 11092 ) | ||
Anticancer drug Name | Paclitaxel (PubChem CID: 36314 ) | ||
Structure of Phytochemical |
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2D
MOL
3D
MOL
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Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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Pair Name | Paeonol, Paclitaxel | |||
Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
Gene Regulation | Down-regulation | Expression | BCRP | KEGG ID N.A. |
Down-regulation | Expression | MRP1 | KEGG ID N.A. | |
Down-regulation | Expression | P-gp | KEGG ID N.A. | |
Down-regulation | Expression | transgelin 2 | KEGG ID N.A. | |
In Vitro Model | MCF-7/PTX | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_C5RS |
Result | These results not only provide insight into the potential application of paeonol to the reversal of paclitaxel resistance, thus facilitating the sensitivity of breast cancer chemotherapy, but also highlight a potential role of transgelin 2 in the development of paclitaxel resistance in breast cancer. |
No. | Title | Href |
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1 | Paeonol reverses paclitaxel resistance in human breast cancer cells by regulating the expression of transgelin 2. Phytomedicine. 2014;21(7):984-991. doi:10.1016/j.phymed.2014.02.012 | Click |